NADH Dehydrogenase 4 (ND4)
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MT-ND4; MTND4; NAD4; NADH-Ubiquinone Oxidoreductase Chain 4; Mitochondrially Encoded NADH Dehydrogenase 4
 HGNC 7459
 MGI 102498
 PubMed 21826063
 RGD 620559
 UniProt P03905
 USCN S950
 Wiki MT-ND4
NADH Dehydrogenase 4 (ND4)
The MT-ND4 gene provides instructions for making a protein called NADH dehydrogenase 4. This protein is part of a large enzyme complex known as complex I, which is active in mitochondria. Mitochondria are structures within cells that convert the energy from food into a form that cells can use. These cellular structures produce energy through a process called oxidative phosphorylation, which uses oxygen and simple sugars to create adenosine triphosphate, the cell's main energy source. Several mutations in the MT-ND4 gene are known to cause Leber hereditary optic neuropathy. Each of these mutations changes a single protein building block in the NADH dehydrogenase 4 protein. One MT-ND4 mutation is the most common cause of Leber hereditary optic neuropathy; it is responsible for about 70 percent of all cases worldwide.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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