Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)
CMH8; MLC1V; VLC1; MLC1SB
 HGNC 7584
 MGI 97268
 PubMed 23594557
 RGD 3142
 UniProt P08590
 USCN D425
 Wiki MYL3
Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3)
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Adenoviral gene transfer of p35 in vivo prevented caspase-3 activation and MYL3 cleavage, with positive impact on contractility. These data suggested that direct cleavage of the myosin light chain by activated caspase-3 may contribute to depression of myocyte function by altering crossbridge interaction between myosin and actin molecules. Therefore, activation of apoptotic pathways in the heart may lead to contractile dysfunction before cell death.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD425Hu01 Recombinant Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) SDS-PAGE; WB; ELISA; IP.
Antibodies MAD425Hu21 Monoclonal Antibody to Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) WB, ICC, IHC-P, IHC-F, ELISA
PAD425Hu01 Polyclonal Antibody to Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SED425Hu ELISA Kit for Myosin Light Chain 3, Alkali, Ventricular, Slow Skeletal (MYL3) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a