Thrombopoietin Receptor (TPOR)

CD110; C-MPL; MPLV; MPL; Thrombopoietin Receptor; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl

Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.

Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB468Hu01 Recombinant Thrombopoietin Receptor (TPOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB468Hu01 Polyclonal Antibody to Thrombopoietin Receptor (TPOR) WB; IHC; ICC; IP.
Assay Kits SEB468Hu ELISA Kit for Thrombopoietin Receptor (TPOR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB468Mu01 Recombinant Thrombopoietin Receptor (TPOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB468Mu01 Polyclonal Antibody to Thrombopoietin Receptor (TPOR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Thrombopoietin Receptor (TPOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thrombopoietin Receptor (TPOR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thrombopoietin Receptor (TPOR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thrombopoietin Receptor (TPOR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thrombopoietin Receptor (TPOR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thrombopoietin Receptor (TPOR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thrombopoietin Receptor (TPOR) ELISA Kit Customized Service Offer