Myeloproliferative Leukemia Virus Oncogene (MPL)
CD110; C-MPL; MPLV; TPOR; Thrombopoietin Receptor
 HGNC 7217
 MGI 97076
 PubMed 24043765
 RGD 1311069
 UniProt P40238
 USCN B468
 Wiki MPL
Myeloproliferative Leukemia Virus Oncogene (MPL)
Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB468Hu01 Recombinant Myeloproliferative Leukemia Virus Oncogene (MPL) SDS-PAGE; WB; ELISA; IP.
Antibodies PAB468Hu01 Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB468Mu01 Recombinant Myeloproliferative Leukemia Virus Oncogene (MPL) SDS-PAGE; WB; ELISA; IP.
Antibodies PAB468Mu01 Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a