MIND Kinetochore Complex Component Homolog (NSL1)
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DC8; MIS14
 HGNC 24548
 MGI 2685830
 PubMed 15502821
 RGD 1590586
 UniProt Q96IY1
 USCN L971
 Wiki NSL1
MIND Kinetochore Complex Component Homolog (NSL1)
NSL1 encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.MIS12 RNA interference (RNAi) abolished the kinetochore localization of DC8, C20ORF127, and ZWINT, and double RNAi against HP1-alpha and HP1-gamma (CBX3) abolished the kinetochore localization of MIS12 and DC8.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a