Leucine Rich Repeat Kinase 2 (LRRK2)
AURA17; PARK8; RIPK7; ROCO2; Dardarin ; Parkinson Disease(Autosomal Dominant)8; Leucine-rich repeat serine/threonine-protein kinase 2
LRRK2 encodes a protein with an ankyrin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, an MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. Expression of mutant LRRK2 induced apoptotic cell death in neuroblastoma cells and in mouse cortical neurons. Mutations in this gene have been associated with Parkinson's disease type 8.Four LRRK2 gene variants found are found in a third of Parkinson’s cases, but infrequent in the general population.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPH716Hu01 | Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPH716Hu02 | Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAH716Hu01 | Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) | WB; IHC; ICC; IP. |
PAH716Hu02 | Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) | WB; IHC; ICC; IP. | |
LAH716Hu71 | Biotin-Linked Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) | WB; IHC; ICC. | |
Assay Kits | SEH716Hu | ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPH716Mu01 | Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAH716Mu01 | Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPH716Ra01 | Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAH716Ra21 | Monoclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) | WB; IHC; ICC; IP. |
PAH716Ra01 | Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) | WB; IHC; ICC; IP. | |
Assay Kits | SEH716Ra | ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) | Enzyme-linked immunosorbent assay for Antigen Detection. |