Leucine Rich Repeat Kinase 2 (LRRK2)
AURA17; PARK8; RIPK7; ROCO2; Dardarin ; Parkinson Disease(Autosomal Dominant)8
 HGNC 18618
 MGI 1913975
 RGD 1561168
 UniProt Q5S007
 USCN H716
Leucine Rich Repeat Kinase 2 (LRRK2)
LRRK2 encodes a protein with an ankyrin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, an MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. Expression of mutant LRRK2 induced apoptotic cell death in neuroblastoma cells and in mouse cortical neurons.
Mutations in this gene have been associated with Parkinson's disease type 8.Four LRRK2 gene variants found are found in a third of Parkinson’s cases, but infrequent in the general population.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH716Hu01 Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) SDS-PAGE; WB; ELISA; IP.
RPH716Hu02 Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) SDS-PAGE; WB; ELISA; IP.
Antibodies PAH716Hu01 Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) WB, ICC, IHC-P, IHC-F, ELISA
PAH716Hu02 Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) WB, ICC, IHC-P, IHC-F, ELISA
PAH716Hu71 Biotin-Linked Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) IHC;WB;ELISA
Assay Kits SEH716Hu ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH716Mu01 Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) SDS-PAGE; WB; ELISA; IP.
Antibodies PAH716Mu01 Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH716Ra01 Recombinant Leucine Rich Repeat Kinase 2 (LRRK2) SDS-PAGE; WB; ELISA; IP.
Antibodies MAH716Ra21 Monoclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) WB, ICC, IHC-P, IHC-F, ELISA
PAH716Ra01 Polyclonal Antibody to Leucine Rich Repeat Kinase 2 (LRRK2) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEH716Ra ELISA Kit for Leucine Rich Repeat Kinase 2 (LRRK2) Enzyme-linked immunosorbent assay