Leucine Rich Repeat Kinase 1 (LRRK1)
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RIPK6; Roco1
 HGNC 18608
 MGI 2142227
 PubMed 23675505
 RGD 1308000
 UniProt Q38SD2
 USCN H717
 Wiki LRRK1
Leucine Rich Repeat Kinase 1 (LRRK1)
LRRK1 has a domain organization similar to that of LRRK2, with 6 N-terminal ankyrin repeats, followed by 14 leucine-rich repeats, a RAS (see HRAS)-like GTPase domain (ROC domain), a C-terminal to ROC (COR) domain, a serine/threonine kinase domain, and 7 C-terminal WD40 repeats. Highest expression of LRRK1 was in testis, placenta, prostate, and muscle, with moderate expression in brain, pancreas, small intestine, stomach, and spleen. LRRK1 underwent intramolecular, but not intermolecular, autophosphorylation. Replacement of lys1269 with trp in the ATP-binding niche of the kinase domain of LRRK1 significantly reduced autophosphorylation activity. LRRK1 also functioned as a GDP/GTP-binding protein, and its kinase activity was stimulated upon binding of GTP to the ROC domain.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a