Lamin A/C (LMNA)
CDCD1; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; PRO1; Cardiomyopathy Dilated 1A; Limb Girdle Muscular Dystrophy 1B; Progeria 1
 HGNC 6636
 MGI 96794
 PubMed 23666920
 RGD 620456
 UniProt P02545
 USCN F550
 Wiki LMNA
Lamin A/C (LMNA)
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution.
Lamin A is targeted to the nuclear membrane by an isoprenyl group but it is cleaved shortly after arriving at the membrane. It stays associated with the membrane through protein-protein interactions of itself and other membrane associated proteins, such as LAP1. Depolymerization of the nuclear lamins leads to disintegration of the nuclear envelope. Transfection experiments demonstrate that phosphorylation of human lamin A is required for lamin depolymerization, and thus for disassembly of the nuclear envelope, which normally occurs early in mitosis.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF550Hu01 Recombinant Lamin A/C (LMNA) SDS-PAGE; WB; ELISA; IP.
Antibodies MAF550Hu21 Monoclonal Antibody to Lamin A/C (LMNA) WB, ICC, IHC-P, IHC-F, ELISA
PAF550Hu01 Polyclonal Antibody to Lamin A/C (LMNA) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEF550Hu ELISA Kit for Lamin A/C (LMNA) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF550Mu01 Recombinant Lamin A/C (LMNA) SDS-PAGE; WB; ELISA; IP.
RPF550Mu02 Recombinant Lamin A/C (LMNA) SDS-PAGE; WB; ELISA; IP.
Antibodies PAF550Mu01 Polyclonal Antibody to Lamin A/C (LMNA) WB, ICC, IHC-P, IHC-F, ELISA
PAF550Mu02 Polyclonal Antibody to Lamin A/C (LMNA) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEF550Mu ELISA Kit for Lamin A/C (LMNA) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF550Ra01 Recombinant Lamin A/C (LMNA) SDS-PAGE; WB; ELISA; IP.
Antibodies MAF550Ra21 Monoclonal Antibody to Lamin A/C (LMNA) WB, ICC, IHC-P, IHC-F, ELISA
PAF550Ra01 Polyclonal Antibody to Lamin A/C (LMNA) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEF550Ra ELISA Kit for Lamin A/C (LMNA) Enzyme-linked immunosorbent assay