Killin (KLLN)
p53-Regulated DNA Replication Inhibitor
Killin is a p53-regulated nuclear inhibitor of DNA synthesis, which lies in close proximity to pten on human chromosome 10 and encodes a 20-kDa nuclear protein. Killin is not only necessary but also sufficient for p53-induced apoptosis. Genetic and biochemical analysis demonstrates that Killin is a high-affinity DNA-binding protein, which potently inhibits eukaryotic DNA synthesis in vitro and appears to trigger S phase arrest before apoptosis in vivo. The DNA-binding domain essential for DNA synthesis inhibition was mapped to within 42 amino acid residues near the N terminus of Killin.
These results support Killin as a missing link between p53 activation and S phase checkpoint control designed to eliminate replicating precancerous cells, should they escape G(1) blockade mediated by p21.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Killin (KLLN) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Killin (KLLN) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Killin (KLLN) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Killin (KLLN) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Killin (KLLN) | ELISA Kit Customized Service Offer |