Keratin 12 (KRT12)
CK12; Cytokeratin 12; Meesmann Corneal Dystrophy
 HGNC 6414
 MGI 96687
 PubMed 16431949
 RGD 1304805
 UniProt Q99456
 USCN A535
 Wiki Keratin_12
Keratin 12 (KRT12)
Keratin 12 is a keratin found expressed in corneal epithelia. Mutations in the gene encoding this protein lead to Meesmann corneal dystrophy. To elucidate the function of keratin 12, Kao et al. (1996) created knockout mice lacking the Krt1.12 gene by gene targeting techniques. The heterozygous mice appeared normal. Homozygous mice developed normally and suffered mild corneal epithelial erosion. The corneal epithelia were fragile and could be removed by gentle rubbing of the eyes or brushing. The corneal epithelium of the homozygotes did not express keratin 12 as judged by immunohistochemistry, Western immunoblot analysis with epitope-specific anti-keratin 12 antibodies, Northern hybridization, and in situ hybridization with an antisense keratin 12 riboprobe.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits SEA535Hu ELISA Kit for Keratin 12 (KRT12) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA535Ra01 Recombinant Keratin 12 (KRT12) SDS-PAGE; WB; ELISA; IP.
Antibodies PAA535Ra01 Polyclonal Antibody to Keratin 12 (KRT12) WB, ICC, IHC-P, IHC-F, ELISA
PAA535Ra71 Biotin-Linked Antibody to Keratin 12 (KRT12) IHC;WB;ELISA
Assay Kits n/a n/a n/a