Intestine Specific Homeobox Protein (ISX)
RAXLX
 HGNC 28084
 MGI 1918847
 UniProt Q2M1V0
 USCN J986
Intestine Specific Homeobox Protein (ISX)
Using expression profiling to identify transcription factors involved in development of the mouse digestive tract, Choi et al. (2006) identified a novel gene, which they they named Isx because of its highly restricted expression pattern in the intestine.
This construct showed that Isx is abundantly expressed in intestinal epithelial cells from the duodenum to the proximal colon. Expression profiling showed further that beta-carotene 15,15-prime-monooxygenase (BCMO1) and Scarb1 were highly upregulated in homozygous knockout animals. BCMO1 is involved in vitamin A synthesis and SCARB1 in carotenoid and cholesterol uptake. Vitamin A deprivation of wildtype mice resulted in decreased Isx and increased Bcmo1 expression. Isx participates in vitamin A metabolism most likely by regulating Bcmo1 expression in the intestine.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a