Interleukin 12B (IL12B)
p40; IL12-B; CLMF2; NKSF2; Natural Killer Cell Stimulatory Factor 2; Cytotoxic Lymphocyte Maturation Factor 2; Interleukin 23, P40 Subunit
 HGNC 5970
 MGI 96540
 OMIM 161561
 RGD 628704
 UCSC uc003lxr.1
 UniProt P29460
 USCN 90058
Interleukin 12B (IL12B)
Interleukin-12 (IL-12) is a proinflammatory cytokine that induces the production of interferon-γ (IFN-γ), favors the differentiation of T helper 1 (TH1) cells and forms a link between innate resistance and adaptive immunity.
Biologically active IL-12 is a heterodimer formed by a 35-kDa light chain (IL-12A) and a 40-kDa heavy chain each encoded by separate genes on different chromosomes.IL12B ssociates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines.
Research reagent products of Interleukin 12B (IL12B)
Organism
ELISA Kit
CLIA Kit
Protein
Antibody
Catalog Manual Catalog Manual Catalog Manual McAb PcAb
Homo sapiens (Human)E90058HuPDFn/an/aP90058Hu01n/aA90058Hu22A90058Hu01
Mus musculus (Mouse)E90058MuPDFn/an/aP90058Mu01n/an/aA90058Mu01
Rattus norvegicus (Rat)E90058RaPDFn/an/aP90058Ra01n/an/aA90058Ra01
Cavia (Guinea pig )E90058GuPDFn/an/aP90058Gu01n/an/aA90058Gu01
Canis familiaris; Canine (Dog)E90058CaPDFn/an/aP90058Ca01n/an/aA90058Ca01
Sus scrofa; Porcine (Pig)E90058PoPDFn/an/aP90058Po01n/an/aA90058Po01
Bos taurus; Bovine (Cattle)E90058BoPDFn/an/aP90058Bo01n/an/aA90058Bo01
Capra hircus; Caprine (Goat)E90058CpPDFn/an/aP90058Cp01n/an/aA90058Cp01
Equus caballus; Equine (Horse)E90058EqPDFn/an/aP90058Eq01n/an/aA90058Eq01
Chicken (Gallus)E90058GaPDFn/an/aP90058Ga01n/an/aA90058Ga01
Rainbow troutE90058FiPDFn/an/aP90058Fi01n/an/aA90058Fi01