Interleukin 1 Receptor Associated Kinase 4 (IRAK4)
NY-REN-64
 HGNC 17967
 MGI 2182474
 RGD 1305303
 UniProt Q9NWZ3
 USCN B518
Interleukin 1 Receptor Associated Kinase 4 (IRAK4)
IRAK-4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors.Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.Unlike the other IRAK proteins, however, but similar to Pelle, IRAK4 has a short C-terminal domain. Northern blot analysis revealed expression of 3.0- and 4.4-kb transcripts, with strongest expression in kidney and liver.
Luciferase reporter analysis showed that IRAK4 lacking the kinase domain inhibited IL1- but not tumor necrosis factor (TNF)- induced NFKB and IRAK1 activation. SDS-PAGE and autoradiographic analysis indicated that IRAK4 phosphorylates and activates IRAK1 at thr387, but not vice versa.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB518Hu01 Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB518Hu22 Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) WB, ICC, IHC-P, IHC-F, ELISA
PAB518Hu01 Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEB518Hu ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB518Ra01 Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB518Ra21 Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) WB, ICC, IHC-P, IHC-F, ELISA
PAB518Ra01 Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEB518Ra ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Enzyme-linked immunosorbent assay