IFNK is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.May play a role in the regulation of immune cell function.

Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.Expressed in keratinocytes, monocytes and in resting dendritic cells.By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon- beta.