Parathyroid hormone receptor 2 is a protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). There is 30 to 70% amino acid sequence identity between receptors within the secretin receptor family, but these receptors have essentially no sequence identity with most known G protein-coupled receptors of the rhodopsin family or with the metabotropic glutamate receptor family. PTHR2 is most similar (51% overall amino acid identity) to the PTH/PTHRP receptor. The PTHR2 gene was most abundantly expressed in brain, pancreas, testis, and placenta.