Inducible T-Cell Co Stimulator (ICOS)
AILIM; CD278; Inducible T-Cell Costimulator; Activation-Inducible Lymphocyte Immunomediatory Molecule
 HGNC 5351
 MGI 1858745
 OMIM 604558
 RGD 620123
 UCSC uc002vam.2
 UniProt Q9Y6W8
 USCN 90777
Inducible T-Cell Co Stimulator (ICOS)
ICOS (Inducible T-cell COStimulator) is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is thought to be important for Th2 cells in particular.The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.Compared to wild-type naïve T cells, ICOS-/- T cells activated with plate-bound anti-CD3 have reduced proliferation and IL-2 secretion(1). The defect in proliferation can be rescued by addition of IL-2 to the culture, suggesting the proliferative defect is due to reduced IL-2 secretion. In terms of Th1 and Th2 cytokine secretion, ICOS-/- CD4+ T cell activated in vitro have reduced IL-4 secretion, but similar IFN-g secretion.
 ELISA Kits(Enzyme-linked immunosorbent assay Kits)
Catalog Product Name Organism Manual
E90777HuELISA Kit for Inducible T-Cell Co Stimulator (ICOS)Homo sapiens (Human)  PDF
E90777MuELISA Kit for Inducible T-Cell Co Stimulator (ICOS)Mus musculus (Mouse)  n/a
E90777RaELISA Kit for Inducible T-Cell Co Stimulator (ICOS)Rattus norvegicus (Rat)  n/a
 CLIA Kits(Chemiluminescent immunoassay Kits)
Catalog Product Name Organism Manual
C90777HuCLIA Kit for Inducible T-Cell Co Stimulator (ICOS)Homo sapiens (Human)  n/a
C90777MuCLIA Kit for Inducible T-Cell Co Stimulator (ICOS)Mus musculus (Mouse)  n/a
C90777RaCLIA Kit for Inducible T-Cell Co Stimulator (ICOS)Rattus norvegicus (Rat)  n/a