Inducible T-Cell Co Stimulator(ICOS)
AILIM; CD278; Inducible T-Cell Costimulator; Activation-Inducible Lymphocyte Immunomediatory Molecule
 H U G O 5351
M   G   I 1858745
O M I M 604558
R   G   D 620123
U C S C uc002vam.2
UniProt Q9Y6W8
USCNK 90777
Inducible T-Cell Co Stimulator(ICOS)
ICOS (Inducible T-cell COStimulator) is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is thought to be important for Th2 cells in particular.The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.Compared to wild-type naïve T cells, ICOS-/- T cells activated with plate-bound anti-CD3 have reduced proliferation and IL-2 secretion(1). The defect in proliferation can be rescued by addition of IL-2 to the culture, suggesting the proliferative defect is due to reduced IL-2 secretion. In terms of Th1 and Th2 cytokine secretion, ICOS-/- CD4+ T cell activated in vitro have reduced IL-4 secretion, but similar IFN-g secretion.
 ELISA Kits(Enzyme-linked immunosorbent assay Kits)
Catalog Product Name Species Packing Price Manual
E90777HuELISA Kit for Human Inducible T-Cell Co Stimulator(ICOS)Humann/an/a   n/a
E90777MuELISA Kit for Mouse Inducible T-Cell Co Stimulator(ICOS)Mousen/an/a   n/a
E90777RaELISA Kit for Rat Inducible T-Cell Co Stimulator(ICOS)Ratn/an/a   n/a
 Antibodies
Catalog Product Name Species Packing Price Manual
A90777HuAntibody to Human Inducible T-Cell Co Stimulator(ICOS)Humann/an/a   n/a
A90777MuAntibody to Mouse Inducible T-Cell Co Stimulator(ICOS)Mousen/an/a   n/a
A90777RaAntibody to Rat Inducible T-Cell Co Stimulator(ICOS)Ratn/an/a   n/a
 CLIA Kits(Chemiluminescent immunoassay Kits)
Catalog Product Name Species Packing Price Manual
C90777HuCLIA Kit for Human Inducible T-Cell Co Stimulator(ICOS)Humann/an/a   n/a
C90777MuCLIA Kit for Mouse Inducible T-Cell Co Stimulator(ICOS)Mousen/an/a   n/a
C90777RaCLIA Kit for Rat Inducible T-Cell Co Stimulator(ICOS)Ratn/an/a   n/a