Huntingtin (HTT)
IT15; HD; Interesting Transcript 15
 HGNC 4851
 MGI 96067
 RGD 68337
 UniProt P42858
 USCN H922
Huntingtin (HTT)
Huntingtin has no sequence homology with other proteins and is highly expressed in neurons and testes in humans and rodents. Huntingtin upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level but the mechanism by which huntingtin regulated gene expression has not been determined. From immunohistochemistry, electron microscopy, and subcellular fractionation studies of the molecule, it has been found that huntingtin is primarily associated with vesicles and microtubules. These appear to indicate a functional role in cytoskeletal anchoring or transport of mitochondria. The Htt protein is involved in vesicle trafficking as it interacts with HIP1, a clathrin binding protein, to mediate endocytosis, the absorption of materials into a cell.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH922Hu01 Recombinant Huntingtin (HTT) SDS-PAGE; WB; ELISA; IP.
Antibodies MAH922Hu21 Monoclonal Antibody to Huntingtin (HTT) WB, ICC, IHC-P, IHC-F, ELISA
PAH922Hu01 Polyclonal Antibody to Huntingtin (HTT) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEH922Hu ELISA Kit for Huntingtin (HTT) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH922Mu01 Recombinant Huntingtin (HTT) SDS-PAGE; WB; ELISA; IP.
RPH922Mu02 Recombinant Huntingtin (HTT) SDS-PAGE; WB; ELISA; IP.
Antibodies PAH922Mu01 Polyclonal Antibody to Huntingtin (HTT) WB, ICC, IHC-P, IHC-F, ELISA
PAH922Mu02 Polyclonal Antibody to Huntingtin (HTT) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEH922Mu ELISA Kit for Huntingtin (HTT) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH922Ra01 Recombinant Huntingtin (HTT) SDS-PAGE; WB; ELISA; IP.
Antibodies MAH922Ra21 Monoclonal Antibody to Huntingtin (HTT) WB, ICC, IHC-P, IHC-F, ELISA
PAH922Ra01 Polyclonal Antibody to Huntingtin (HTT) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEH922Ra ELISA Kit for Huntingtin (HTT) Enzyme-linked immunosorbent assay