Heparanase 2 (HPA2)
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HPSE2; HPR2
 HGNC 18374
 MGI 2685814
 PubMed 20576607
 UniProt Q8WWQ2
 USCN D395
 Wiki HPSE2
Heparanase 2 (HPA2)
Heparanase-2 is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.
Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti-cancer therapies.Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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