Glycoprotein 96 is a cell surface protein that binds adenosine. Thus, gp96 is also called adenotin and it is similar to various stress-induced proteins. The gp96 serves as a natural adjuvant for chaperoning antigenic peptides into the immune surveillance pathways.Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II-Restricted Epitopes for In Vivo Presentation, but Selectively Primes CD8 T Cell Effector Function gp96 facilitated the cross-presentation of a class I-restricted peptide and priming of effector function in cognate CD8 cells. Interestingly, gp96 also facilitated the in vivo presentation of a class II-restricted peptide; however, the resulting CD4 cell response did not involve the development of effector function. Taken together, these data suggest that gp96 is an inflammatory mediator that selectively primes CD8 cell effector function.