Ras GTPase Activating Protein 1 (RASA1)
Ras-GAP; RasGAP; CM-AVM; CMAVM; GAP; PKWS; RASA; P120GAP; RAS P21 Protein Activator 1; Capillary Malformation-Arteriovenous Malformation
 HGNC 9871
 MGI 97860
 PubMed 15917201
 RGD 3537
 UniProt P20936
 USCN B616
 Wiki RASA1
Ras GTPase Activating Protein 1 (RASA1)
RAS p21 protein activator 1 is a 120-kDa cytosolic human protein that provides two principal activities:Inactivation of Ras from its active GTP-bound form to its unactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains. The protein is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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Proteins n/a n/a n/a
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