Friend Leukemia Virus Integration 1 (FLI1)
EWSR2; SIC1; Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB
Friend leukemia virus integration 1 is memeber of ETS transcription factor that first identified in erythroleukemias induced by Friend Murine Leukemia Virus (F-MuLV). Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias.
The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC492Hu01 | Recombinant Friend Leukemia Virus Integration 1 (FLI1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC492Hu01 | Polyclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Friend Leukemia Virus Integration 1 (FLI1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Friend Leukemia Virus Integration 1 (FLI1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Friend Leukemia Virus Integration 1 (FLI1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Friend Leukemia Virus Integration 1 (FLI1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Friend Leukemia Virus Integration 1 (FLI1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Friend Leukemia Virus Integration 1 (FLI1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Friend Leukemia Virus Integration 1 (FLI1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Friend Leukemia Virus Integration 1 (FLI1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Friend Leukemia Virus Integration 1 (FLI1) | ELISA Kit Customized Service Offer |