Folliculin (FLCN)
BHD; FLCL; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein
Using coimmunoprecipitation of FNIP1 and FLCN expressed in HEK293 cells and in vitro binding assays, the C-terminus of FLCN and amino acids 300 to 1166 of FNIP1 were shown to be required for optimal FLCN-FNIP1 binding. FLCN and FNIP1 colocalized to the cytoplasm in a reticular pattern. FNIP1 was phosphorylated by AMPK and its phosphorylation was inhibited in a dose-dependent manner by an AMPK inhibitor, resulting in reduced FNIP1 expression. FLCN phosphorylation was diminished by rapamycin and amino acid starvation and facilitated by FNIP1 overexpression, suggesting that FLCN phosphorylation may be regulated by mTOR and AMPK signaling. FLCN and FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPJ102Hu01 | Recombinant Folliculin (FLCN) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAJ102Hu01 | Polyclonal Antibody to Folliculin (FLCN) | WB; IHC; ICC; IP. |
LAJ102Hu71 | Biotin-Linked Polyclonal Antibody to Folliculin (FLCN) | WB; IHC; ICC. | |
MAJ102Hu21 | Monoclonal Antibody to Folliculin (FLCN) | WB; IHC; ICC; IP. | |
Assay Kits | SEJ102Hu | ELISA Kit for Folliculin (FLCN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Folliculin (FLCN) | Recombinant Protein Customized Service Offer |
Antibodies | PAJ102Mu01 | Polyclonal Antibody to Folliculin (FLCN) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Folliculin (FLCN) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Folliculin (FLCN) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Folliculin (FLCN) | Recombinant Protein Customized Service Offer |
Antibodies | PAJ102Ra01 | Polyclonal Antibody to Folliculin (FLCN) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Folliculin (FLCN) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Folliculin (FLCN) | ELISA Kit Customized Service Offer |