Folliculin (FLCN)
BHD; FLCL
 HGNC 27310
 MGI 2442184
 PubMed 24081491
 RGD 735088
 UniProt Q8NFG4
 USCN J102
 Wiki Folliculin
Folliculin (FLCN)
Using coimmunoprecipitation of FNIP1 and FLCN expressed in HEK293 cells and in vitro binding assays, the C-terminus of FLCN and amino acids 300 to 1166 of FNIP1 were shown to be required for optimal FLCN-FNIP1 binding. FLCN and FNIP1 colocalized to the cytoplasm in a reticular pattern. FNIP1 was phosphorylated by AMPK and its phosphorylation was inhibited in a dose-dependent manner by an AMPK inhibitor, resulting in reduced FNIP1 expression. FLCN phosphorylation was diminished by rapamycin and amino acid starvation and facilitated by FNIP1 overexpression, suggesting that FLCN phosphorylation may be regulated by mTOR and AMPK signaling. FLCN and FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ102Hu01 Recombinant Folliculin (FLCN) SDS-PAGE; WB; ELISA; IP.
Antibodies MAJ102Hu21 Monoclonal Antibody to Folliculin (FLCN) WB, ICC, IHC-P, IHC-F, ELISA
PAJ102Hu01 Polyclonal Antibody to Folliculin (FLCN) WB, ICC, IHC-P, IHC-F, ELISA
PAJ102Hu71 Biotin-Linked Antibody to Folliculin (FLCN) IHC;WB;ELISA
Assay Kits SEJ102Hu ELISA Kit for Folliculin (FLCN) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies PAJ102Mu01 Polyclonal Antibody to Folliculin (FLCN) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies PAJ102Ra01 Polyclonal Antibody to Folliculin (FLCN) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a