Folliculin (FLCN)

BHD; FLCL; BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein

Using coimmunoprecipitation of FNIP1 and FLCN expressed in HEK293 cells and in vitro binding assays, the C-terminus of FLCN and amino acids 300 to 1166 of FNIP1 were shown to be required for optimal FLCN-FNIP1 binding. FLCN and FNIP1 colocalized to the cytoplasm in a reticular pattern. FNIP1 was phosphorylated by AMPK and its phosphorylation was inhibited in a dose-dependent manner by an AMPK inhibitor, resulting in reduced FNIP1 expression. FLCN phosphorylation was diminished by rapamycin and amino acid starvation and facilitated by FNIP1 overexpression, suggesting that FLCN phosphorylation may be regulated by mTOR and AMPK signaling. FLCN and FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPJ102Hu01Recombinant Folliculin (FLCN)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAJ102Hu01Polyclonal Antibody to Folliculin (FLCN)WB, ICC, IHC-P, IHC-F, ELISA
LAJ102Hu71Biotin-Linked Polyclonal Antibody to Folliculin (FLCN)IHC;WB;ELISA
MAJ102Hu21Monoclonal Antibody to Folliculin (FLCN)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEJ102HuELISA Kit for Folliculin (FLCN)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Folliculin (FLCN)Recombinant Protein Customized Service Offer
AntibodiesPAJ102Mu01Polyclonal Antibody to Folliculin (FLCN)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Folliculin (FLCN)CLIA Kit Customized Service Offer
n/aELISA Kit for Folliculin (FLCN)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Folliculin (FLCN)Recombinant Protein Customized Service Offer
AntibodiesPAJ102Ra01Polyclonal Antibody to Folliculin (FLCN)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Folliculin (FLCN)CLIA Kit Customized Service Offer
n/aELISA Kit for Folliculin (FLCN)ELISA Kit Customized Service Offer