Fibroblast Growth Factor 3 (FGF3)
HBGF3; INT2; Murine Mammary Tumor Virus Integration Site(v-int-2)Oncogene Homolog; INT-2 Proto-Oncogene Protein
 HGNC 3681
 MGI 95517
 OMIM 164950
 RGD 620126
 UCSC uc001oph.2
 UniProt P11487
 USCN 92906
Fibroblast Growth Factor 3 (FGF3)
FGF3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.
The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.
Research reagent products of Fibroblast Growth Factor 3 (FGF3)
Organism
Protein
Antibody
ELISA Kit
CLIA Kit
Catalog Manual McAb PcAb Catalog Manual Catalog Manual
Homo sapiens (Human)rP92906Hu01PDFmA92906Hu22pA92906Hu01 sE92906HuPDFsC92906HuPDF
Mus musculus (Mouse)n/an/an/an/a sE92906MuPDFsC92906MuPDF
Rattus norvegicus (Rat)n/an/an/an/a sE92906RaPDFsC92906RaPDF