Fanconi Anemia Complementation Group G (FANCG)
FAG; XRCC9; DNA Repair Protein XRCC9; X-Ray Repair,Complementing Defective,In Chinese Hamster 9
, involved in Fanconi anemia, confers resistance to both hygromycin and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. Fanconi anemia is an autosomal recessive disorder with diverse clinical symptoms, including developmental anomalies, bone marrow failure, and early occurrence of malignancies. A minimum of 8 FA genes have been identified. The putative 622-amino acid protein has a leucine zipper motif at its N terminus, but the authors found no significant similarity to any known protein. In human and baboon tissues, 2 major mRNA bands of 2.2 and 2.5 kb were detected, with highest levels in testis and thymus in human, and in testis in baboon.