Fanconi Anemia Complementation Group F (FANCF)
FAF
 HGNC 3587
 MGI 3689889
 PubMed 23440494
 UniProt Q9NPI8
 USCN K194
 Wiki FANCF
Fanconi Anemia Complementation Group F (FANCF)
FANCF was found predominantly in the nucleus, where it complexes with FANCA, FANCC, and FANCG . These interactions were detected in wildtype and FANCD (FANCD2) lymphoblasts, but not in lymphoblasts of other FA complementation groups. The authors hypothesized that each of the FA proteins, except FANCD, is required for complex formation, and that the multiprotein FA complex serves a nuclear function to maintain genomic integrity.FANCF gene encodes a polypeptide with homology to the prokaryotic RNA-binding protein ROM. The region of homology with ROM comprises the N terminus of the prokaryotic protein, which is the region involved in RNA binding. The homologous region in FANCF is predicted to form an alpha-helical structure.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a