FIP1 Like Protein 1 (FIP1L1)

Rhe; Pre-mRNA 3'-end-processing factor FIP1; Factor interacting with PAP; Rearranged in hypereosinophilia

FIP1L1encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FIP1 Like Protein 1 (FIP1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FIP1 Like Protein 1 (FIP1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FIP1 Like Protein 1 (FIP1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FIP1 Like Protein 1 (FIP1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FIP1 Like Protein 1 (FIP1L1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FIP1 Like Protein 1 (FIP1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FIP1 Like Protein 1 (FIP1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FIP1 Like Protein 1 (FIP1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FIP1 Like Protein 1 (FIP1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FIP1 Like Protein 1 (FIP1L1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FIP1 Like Protein 1 (FIP1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FIP1 Like Protein 1 (FIP1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FIP1 Like Protein 1 (FIP1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FIP1 Like Protein 1 (FIP1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for FIP1 Like Protein 1 (FIP1L1) ELISA Kit Customized Service Offer