Egl Nine Homolog 1 (EGLN1)
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ECYT3; HIFPH2; PHD2; SM-20; SM20; ZMYND6; HIF Prolyl Hydroxylase 2
 HGNC 1232
 MGI 1932286
 PubMed 20956315
 RGD 631375
 UniProt Q9GZT9
 USCN L644
 Wiki EGLN1
Egl Nine Homolog 1 (EGLN1)
EGLN1 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. The genes encoding these proteins were cloned and termed PHD1, PHD2, and PHD3 by the authors. Direct modulation of recombinant enzyme activity by graded hypoxia, iron chelation, and cobaltous ions mirrored the characteristics of HIF induction in vivo, fulfilling requirements for these enzymes being oxygen sensors that regulate HIF.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL644Hu01 Recombinant Egl Nine Homolog 1 (EGLN1) SDS-PAGE; WB; ELISA; IP.
Antibodies MAL644Hu21 Monoclonal Antibody to Egl Nine Homolog 1 (EGLN1) WB, ICC, IHC-P, IHC-F, ELISA
PAL644Hu01 Polyclonal Antibody to Egl Nine Homolog 1 (EGLN1) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEL644Hu ELISA Kit for Egl Nine Homolog 1 (EGLN1) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL644Mu01 Recombinant Egl Nine Homolog 1 (EGLN1) SDS-PAGE; WB; ELISA; IP.
RPL644Mu02 Recombinant Egl Nine Homolog 1 (EGLN1) SDS-PAGE; WB; ELISA; IP.
Antibodies PAL644Mu01 Polyclonal Antibody to Egl Nine Homolog 1 (EGLN1) IWB, ICC, IHC-P, IHC-F, ELISA
PAL644Mu02 Polyclonal Antibody to Egl Nine Homolog 1 (EGLN1) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEL644Mu ELISA Kit for Egl Nine Homolog 1 (EGLN1) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a