Dynactin 1 (DCTN1)
DAP-150; DP-150; P135; p150,Glued Homolog; 150 kDa dynein-associated polypeptide
Dynactin subunit 1 is a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) .
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dynactin 1 (DCTN1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dynactin 1 (DCTN1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dynactin 1 (DCTN1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dynactin 1 (DCTN1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dynactin 1 (DCTN1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dynactin 1 (DCTN1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dynactin 1 (DCTN1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dynactin 1 (DCTN1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dynactin 1 (DCTN1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dynactin 1 (DCTN1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dynactin 1 (DCTN1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dynactin 1 (DCTN1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dynactin 1 (DCTN1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dynactin 1 (DCTN1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dynactin 1 (DCTN1) | ELISA Kit Customized Service Offer |