DnaJ/HSP40 Homolog Subfamily C, Member 5 (DNAJC5)
CSP; DNAJC5a
 HGNC 16235
 MGI 892995
 RGD 620516
 UniProt Q9H3Z4
 USCN K135
DnaJ/HSP40 Homolog Subfamily C, Member 5 (DNAJC5)
The 198-amino acid rat Csp protein contains an N-terminal J domain, followed by a cysteine string and a C-terminal domain. They noted that most of the cysteines are palmitoylated and are required for membrane targeting of Csp. rat CSP binding sites for G proteins, one that overlaps the J domain and binds G-alpha subunits, and another between the J domain and cysteine string that binds G-beta (see GNB1) and/or the G-alpha-beta-gamma trimer.
The complex functioned as an ATP-dependent chaperone that reactivated a denatured substrate. Sgt overexpression in cultured rat hippocampal neurons inhibited neurotransmitter release, suggesting that the Csp/Sgt/Hsc70 complex is important for maintenance of a normal synapse.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a