Dihydropyrimidine Dehydrogenase (DPYD)
DPD; DHPDHase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase
Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and Tegafur-uracil.The sequence of the gene suggested that DPD has at least 3 distinct domains: a possible NADPH binding site and FAD-binding site in the N terminus, 2 motifs of putative iron/sulfur-binding sites near the C terminus, and a peptide domain corresponding to the uracil-binding site.
Expression of the pig enzyme in E. coli catalyzed the reduction of uracil, thymine, and 5-fluorouracil (5FU) with kinetics approximating those published for the enzyme purified from mammalian liver.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC012Hu01 | Recombinant Dihydropyrimidine Dehydrogenase (DPYD) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC012Hu01 | Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) | WB; IHC; ICC; IP. |
MAC012Hu22 | Monoclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) | WB; IHC; ICC; IP. | |
MAC012Hu21 | Monoclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) | WB; IHC; ICC; IP. | |
Assay Kits | SEC012Hu | ELISA Kit for Dihydropyrimidine Dehydrogenase (DPYD) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC012Mu01 | Recombinant Dihydropyrimidine Dehydrogenase (DPYD) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPC012Mu02 | Recombinant Dihydropyrimidine Dehydrogenase (DPYD) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAC012Mu01 | Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) | WB; IHC; ICC; IP. |
PAC012Mu02 | Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) | WB; IHC; ICC; IP. | |
Assay Kits | SEC012Mu | ELISA Kit for Dihydropyrimidine Dehydrogenase (DPYD) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Dihydropyrimidine Dehydrogenase (DPYD) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Dihydropyrimidine Dehydrogenase (DPYD) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Dihydropyrimidine Dehydrogenase (DPYD) | ELISA Kit Customized Service Offer |