Dihydropyrimidine Dehydrogenase (DPYD)
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DPD; DHPDHase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase
 HGNC 3012
 MGI 2139667
 PubMed 20920994
 RGD 621218
 UniProt Q12882
 USCN C012
 Wiki DPYD
Dihydropyrimidine Dehydrogenase (DPYD)
Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and Tegafur-uracil.The sequence of the gene suggested that DPD has at least 3 distinct domains: a possible NADPH binding site and FAD-binding site in the N terminus, 2 motifs of putative iron/sulfur-binding sites near the C terminus, and a peptide domain corresponding to the uracil-binding site.
Expression of the pig enzyme in E. coli catalyzed the reduction of uracil, thymine, and 5-fluorouracil (5FU) with kinetics approximating those published for the enzyme purified from mammalian liver.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC012Hu01 Recombinant Dihydropyrimidine Dehydrogenase (DPYD) SDS-PAGE; WB; ELISA; IP.
Antibodies MAC012Hu22 Monoclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) WB, ICC, IHC-P, IHC-F, ELISA
PAC012Hu01 Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC012Hu ELISA Kit for Dihydropyrimidine Dehydrogenase (DPYD) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC012Mu01 Recombinant Dihydropyrimidine Dehydrogenase (DPYD) SDS-PAGE; WB; ELISA; IP.
RPC012Mu02 Recombinant Dihydropyrimidine Dehydrogenase (DPYD) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC012Mu01 Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) WB, ICC, IHC-P, IHC-F, ELISA
PAC012Mu02 Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC012Mu ELISA Kit for Dihydropyrimidine Dehydrogenase (DPYD) Enzyme-linked immunosorbent assay
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a