Cytochrome P450 27B1 (CYP27B1)
VDD1, PDDR; CYP1, P450c1; 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase; Cytochrome P450 Family 27 Subfamily B Polypeptide 1; Calcidiol 1-monooxygenase; VD3 1A hydroxylase
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CYP27B1 isa member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position.
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This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD539Hu01 | Recombinant Cytochrome P450 27B1 (CYP27B1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD539Hu01 | Polyclonal Antibody to Cytochrome P450 27B1 (CYP27B1) | WB; IHC; ICC; IP. |
Assay Kits | SED539Hu | ELISA Kit for Cytochrome P450 27B1 (CYP27B1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD539Mu01 | Recombinant Cytochrome P450 27B1 (CYP27B1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPD539Mu02 | Recombinant Cytochrome P450 27B1 (CYP27B1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAD539Mu01 | Polyclonal Antibody to Cytochrome P450 27B1 (CYP27B1) | WB; IHC; ICC; IP. |
PAD539Mu02 | Polyclonal Antibody to Cytochrome P450 27B1 (CYP27B1) | WB; IHC; ICC; IP. | |
Assay Kits | SED539Mu | ELISA Kit for Cytochrome P450 27B1 (CYP27B1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD539Ra01 | Recombinant Cytochrome P450 27B1 (CYP27B1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD539Ra01 | Polyclonal Antibody to Cytochrome P450 27B1 (CYP27B1) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Cytochrome P450 27B1 (CYP27B1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Cytochrome P450 27B1 (CYP27B1) | ELISA Kit Customized Service Offer |