Cyclin Dependent Kinase 5 (CDK5)
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PSSALRE
 HGNC 1774
 MGI 101765
 PubMed 11584302
 RGD 70514
 UniProt Q00535
 USCN A739
 Wiki CDK5
Cyclin Dependent Kinase 5 (CDK5)
Recently Cdk5 has emerged as an essential kinase in sensory pathways. Recent reports of Pareek et al. from NIH suggest its necessity in pain signaling. CDK5 is required for proper development of the brain and to be activated, CDK5 must associate with CDK5R1 or CDK5R2. Unlike other cyclin dependent kinases, CDK5 does not also require phosphorylation on the T loop so that binding with the activator is sufficient to activate the kinase. Cdk5 is involved in the processes of neuronal maturation and migration, phosphorylating the key intracellular adaptor of the reelin signaling chain.Experiments performed on mice lacking p35, a necessary activator of cdk5 in early brain development, showed that the normal layering of neurons was reversed in the cortex.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA739Hu01 Recombinant Cyclin Dependent Kinase 5 (CDK5) SDS-PAGE; WB; ELISA; IP.
Antibodies MAA739Hu21 Monoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB, ICC, IHC-P, IHC-F, ELISA
PAA739Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB, ICC, IHC-P, IHC-F, ELISA
PAA739Hu71 Biotin-Linked Antibody to Cyclin Dependent Kinase 5 (CDK5) IHC;WB;ELISA
PAA739Hu81 FITC-Linked Antibody to Cyclin Dependent Kinase 5 (CDK5) IHC;ICC;IF;WB
Assay Kits SEA739Hu ELISA Kit for Cyclin Dependent Kinase 5 (CDK5) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA739Ra01 Recombinant Cyclin Dependent Kinase 5 (CDK5) SDS-PAGE; WB; ELISA; IP.
Antibodies MAA739Ra21 Monoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) WB, ICC, IHC-P, IHC-F, ELISA
PAA739Ra01 Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5) IWB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEA739Ra ELISA Kit for Cyclin Dependent Kinase 5 (CDK5) Enzyme-linked immunosorbent assay