Constitutive Androstane Receptor (CAR)
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NR1I3; NR1-I3; CAR1; MB67; Nuclear Receptor Subfamily 1,Group I,Member 3; Constitutive active response; Constitutive activator of retinoid response; Orphan nuclear receptor MB67
 HGNC 7969
 MGI 1346307
 PubMed 22098234
 RGD 621400
 UniProt Q14994
 USCN C422
 Wiki CAR
Constitutive Androstane Receptor (CAR)
CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits SEC422Hu ELISA Kit for Constitutive Androstane Receptor (CAR) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC422Mu01 Recombinant Constitutive Androstane Receptor (CAR) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC422Mu01 Polyclonal Antibody to Constitutive Androstane Receptor (CAR) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC422Ra01 Recombinant Constitutive Androstane Receptor (CAR) SDS-PAGE; WB; ELISA; IP.
Antibodies PAC422Ra01 Polyclonal Antibody to Constitutive Androstane Receptor (CAR) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEC422Ra ELISA Kit for Constitutive Androstane Receptor (CAR) Enzyme-linked immunosorbent assay