CCR4 NOT Transcription Complex Subunit 6 (CNOT6)
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CCR4
 HGNC 14099
 MGI 2144529
 RGD 1310783
 UniProt Q9ULM6
 USCN P308
CCR4 NOT Transcription Complex Subunit 6 (CNOT6)
CNOT6 contains 575 amino acids. RT-PCR ELISA detected variable expression in all fetal and adult tissues and specific brain regions examined. Highest expression was in adult brain, testis, ovary, spinal cord, and caudate nucleus, and lowest expression was in pancreas and spleen. Expression in fetal brain was lower than that in adult brain.CNOT6 augments the ligand-dependent transcriptional activation of a wide variety of nuclear receptors, including RARA, THRA, RXRA, ESR1, and GCCR, through an NIF1 coactivator complex. siRNA-mediated silencing of endogenous CNOT6 resulted in a marked decrease in nuclear receptor activation as well as attenuated stimulation of RARA target genes, including SOX9 and HOXA1. siRNA knockdown of NIF1, with which CNOT6 associates in vivo, blocked the ligand-dependent potentiating effect of CNOT6.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a