Bufotenine; 5-HO-DMT; 5-OH-DMT; 5-Hydroxy-Dimethyltryptamine; N,N-Dimethyl-5-Hydroxytryptamine; Dimethyl Serotonin; Mappine;cebilcin
is a tryptamine related to the neurotransmitter serotonin. It is an alkaloid found in the skin of some species of toads; in mushrooms, higher plants, and mammals.Bufotenin is similar in chemical structure to the psychedelics psilocin (4-HO-DMT), 5-MeO-DMT, and DMT, chemicals which also occur in some of the same plant and animal species as bufotenin. Psychedelic effects of bufotenin in humans have been observed in some studies.
Bufotenine was first isolated, from toad skin, and named by the Austrian chemist Handovsky at the University of Prague during World War I. The structure of bufotenine was first confirmed in 1934 by Heinrich Wieland’s laboratory in Munich, and the first reported synthesis of bufotenine was by Toshio Hoshino in 1936.