Bone Morphogenetic Protein Receptor II(BMPRII)
BMPR2; BMPR-II; BRK3; T-ALK; BMPR3; PPH1; Primary Pulmonary Hypertension 1
Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic proteins, members of the TGF beta superfamily of ligands. BMPs are involved in host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which it phosphorylates.
The Type I receptor phosphorylates an R-SMAD a transcriptional regulator.Unlike the TGFβ type II receptor, which has a high affinity for TGF-β1, BMPR2 does not have a high affinity for BMP-2, BMP-7 and BMP-4, unless it is co-expressed with a type I BMP receptor. In TGF beta signaling all of the receptors exist in homodimers before ligand binding.
ELISA Kits(Enzyme-linked immunosorbent assay Kits)
Antibodies
| Catalog |
Product Name |
Species |
Packing |
Price |
Manual |
| A90016Hu | Antibody to Human Bone Morphogenetic Protein Receptor II(BMPRII) | Human | n/a | n/a | n/a |
| A90016Mu | Antibody to Mouse Bone Morphogenetic Protein Receptor II(BMPRII) | Mouse | n/a | n/a | n/a |
| A90016Ra | Antibody to Rat Bone Morphogenetic Protein Receptor II(BMPRII) | Rat | n/a | n/a | n/a |
CLIA Kits(Chemiluminescent immunoassay Kits)
| Catalog |
Product Name |
Species |
Packing |
Price |
Manual |
| C90016Hu | CLIA Kit for Human Bone Morphogenetic Protein Receptor II(BMPRII) | Human | n/a | n/a | n/a |
| C90016Mu | CLIA Kit for Mouse Bone Morphogenetic Protein Receptor II(BMPRII) | Mouse | n/a | n/a | n/a |
| C90016Ra | CLIA Kit for Rat Bone Morphogenetic Protein Receptor II(BMPRII) | Rat | n/a | n/a | n/a |