Bone Marrow Stromal Cell Antigen 2 (BST2)
Tetherin; CD317
 HGNC 1119
 MGI 1916800
 RGD 727849
 UniProt Q10589
 USCN B777
Bone Marrow Stromal Cell Antigen 2 (BST2)
Tetherin is a type 2 integral membrane protein, with the N-terminus in the cytoplasm, one membrane spanning domain, and a C-terminus modified by the addition of a glycosyl-phosphatidylinositol (gpi) anchor. When the virion buds from the surface of the cell, one of the tetherin membrane domains is in the new viral membrane, the other remains in the plasma membrane, tethering the virion to the cell. It is antagonized by the viral protein Vpu which is thought to work by targetting tetherin for degredation via the β-TrCP2 dependent pathway.
Tetherin exists as a dimer on the surface of cells, and prevention of dimerisation by mutating the cystine residues, prevents tetherin from inhibiting virus release, although it is still detectable in the cell.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB777Hu01 Recombinant Bone Marrow Stromal Cell Antigen 2 (BST2) SDS-PAGE; WB; ELISA; IP.
Antibodies MAB777Hu22 Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) WB, ICC, IHC-P, IHC-F, ELISA
PAB777Hu01 Polyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2) WB, ICC, IHC-P, IHC-F, ELISA
Assay Kits SEB777Hu ELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2) Enzyme-linked immunosorbent assay
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a