BTB/POZ Domain Containing Protein 12 (BTBD12)
Structure-specific endonuclease subunit SLX4
BTBD12 functions as a critical scaffold element for the assembly of a multiprotein complex containing enzymes involved in DNA maintenance and repair.Similar complexes were detected in other human cell lines examined. Domain analysis showed that MSH2-MSH3, ERCC4-ERCC1, and C20ORF94 associated with the N-terminal region of SLX4, while TERF2-TERF2IP, MUS81-EME1, and PLK1 bound the C-terminal region of SLX4. SLX1 associated with the extreme C terminus of SLX4. The SLX4 complex was recruited to sites of DNA damage and repaired 3-prime flap, 5-prime flap, and replication fork structures, consistent with the activities of the SLX4-associated DNA repair factors. The SLX1-SLX4 module specifically promoted symmetrical cleavage of static and migrating Holliday junctions.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant BTB/POZ Domain Containing Protein 12 (BTBD12) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant BTB/POZ Domain Containing Protein 12 (BTBD12) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant BTB/POZ Domain Containing Protein 12 (BTBD12) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) | ELISA Kit Customized Service Offer |