Bcl2 Associated Athanogene 3 (BAG3)
BIS; CAIR1; BAG Family Molecular Chaperone Regulator 3; Bcl-2-binding protein Bis; Docking protein CAIR-1
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. BAG3 contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC335Hu01 | Recombinant Bcl2 Associated Athanogene 3 (BAG3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC335Hu01 | Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) | WB; IHC; ICC; IP. |
MAC335Hu22 | Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) | WB; IHC; ICC; IP. | |
Assay Kits | SEC335Hu | ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Bcl2 Associated Athanogene 3 (BAG3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Bcl2 Associated Athanogene 3 (BAG3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Bcl2 Associated Athanogene 3 (BAG3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Bcl2 Associated Athanogene 3 (BAG3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Bcl2 Associated Athanogene 3 (BAG3) | ELISA Kit Customized Service Offer |