Aristaless Like Homeobox Protein 4 (ALX4)
FPP; PFM; PFM1; PFM2; Parietal Foramina 2
 HGNC 450
 MGI 108359
 PubMed 22829454
 RGD 1310201
 UniProt Q9H161
 USCN J969
 Wiki ALX4
Aristaless Like Homeobox Protein 4 (ALX4)
ALX4 encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
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