Anti-Apolipoprotein Antibodies (AAHA)
Anti-Apolipoprotein H; Anti β2 Glycoprotein I Antibody
(AAHA) antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and strongly associate with thrombitic forms of lupus.. As a result AAHA are strongly implicated in autoimmune deep vein thrombosis.
Also, it was proposed that AAHA is responsible for lupus anticoagulant. However, antiphospholipid antibodies bind phospholipids at sites similar to sites bound by anti-coagulants such as PAP1 sites and augment anti-coagulation activity. This contrasts with the major, specific, activity of AAHA, defining a subset of anti-cardiolipin antibodies that specifically interacts with Apo-H. AHAA only inhibits the anti-coagulation activity in the presence of Apo-H and the AAHA component of ACLA correlates with a history of frequent thrombosis.