Anti-Insulin Receptor Antibody (AIRA)
Antiinsulin Receptor Autoantibodies
Antiinsulin Receptor Autoantibodies
| USCN | 90511 |
-90511.jpg "Anti-Insulin Receptor Antibody (AIRA)")
Anti-insulin Receptor Autoantibodies Induce Insulin Receptors to Constitutively Associate with Insulin Receptor Substrate-1 and -2 and Cause Severe Cell Resistance to Both Insulin and Insulin-Like Growth Factor I
Autoimmune Thrombocytopenia and Primary Biliary Cirrhosis with Hypoglycemia and Insulin Receptor Autoantibodies.Effects of anti-insulin receptor antibodies (AIRA) on downregulation and turnover of insulin receptors on cultured hepatocytes.
AIRA downregulated insulin receptors on cultured hepatocytes by accelerating their rate of disappearance, inhibition of protein synthesis prevented AIRA-mediated downregulation, and downregulation by AIRA of insulin binding may be partially responsible for the desensitization of target cells to some of the insulin-like actions of these autoantibodies.
Research reagent products of Anti-Insulin Receptor Antibody (AIRA)
