Anti-actin antibodies are found at increased frequency in certain autoimmune diseases and may be of some diagnostic value.In coeliac disease anti-actin antibodies correlated with the level of intestinal damage.In autoimmune hepatitis anti-actin antibodies correlate with patterns of immune recognition, the pattern of recognition was specific to a small percentage of auto-immune hepatitis type 1 or cryptogenic hepatitis patients.in gastric cancer anti-actin antibodies were elevated, along with other antibodies in severe disease with poor outcomes.

Previous studies have demonstrated that serum anti-actin antibodies are a reliable marker of intestinal damage severity in coeliac disease.Serum anti-actin IgA antibodies (AAA) were identified in patients with celiac disease (CD), and a close correlation emerged between the presence of AAA and mucosa damage, but test for AAA found in celiacs have a wide range of sensitivity and specificity values.