ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1)
ATP2A; SERCA1
 HGNC 811
 MGI 105058
 PubMed 12032137
 RGD 621293
 UniProt O14983
 USCN G373
 Wiki ATP2A1
ATPase, Ca++ Transporting, Cardiac Muscle, Fast Twitch 1 (ATP2A1)
ATP2A1 encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms.
In cotransfection experiments, S1T proteins consistently reduced the higher steady state Ca(2+) level in ER following SERCA1 or SERCA2B overexpression.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME APPLICATIONS
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Assay Kits n/a n/a n/a
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME APPLICATIONS
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Antibodies n/a n/a n/a
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Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a n/a n/a
Antibodies n/a n/a n/a
Assay Kits n/a n/a n/a