A Disintegrin And Metalloprotease 17 (ADAM17)
CD156b; TACE; CSVP; Tumor Necrosis Factor,Alpha,Converting Enzyme; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease
ADAM17 is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha;) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha;), and is of known physiological importance.
ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | SEB555Mu | ELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB555Ra01 | Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB555Ra01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC; IP. |
MAB555Ra21 | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC; IP. | |
Assay Kits | SEB555Ra | ELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17) | Enzyme-linked immunosorbent assay for Antigen Detection. |