3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR)
HMG-CoA Reductase; Hydroxymethylglutaryl-CoA Reductase
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.
Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor as well as oxidized species of cholesterol. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | Recombinant Protein Customized Service Offer |
Antibodies | PAD686Hu01 | Polyclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | WB; IHC; ICC; IP. |
Assay Kits | SED686Hu | ELISA Kit for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD686Ra01 | Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD686Ra01 | Polyclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | WB; IHC; ICC; IP. |
MAD686Ra21 | Monoclonal Antibody to 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | WB; IHC; ICC; IP. | |
Assay Kits | SED686Ra | ELISA Kit for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) | Enzyme-linked immunosorbent assay for Antigen Detection. |